In recent years, oral spironolactone has become an increasingly popular option for the long-term control of cystic acne in women. Even though it is not FDA approved for the treatment of acne, large studies have demonstrated its safety and effectiveness. Spironolactone is ideal for those women who experience premenstrual flares, those who wish to avoid oral antibiotics, or for those who flare with acne after discontinuing oral antibiotics.
The Acne Center of Michigan offers a specialized topical version of spironolactone (Acne DS Clarifying Gel™) that is highly effective in controlling hormonal flares of acne in women. There are no significant side effects from the topical version of spironolactone and the medication is well-tolerated, even in those with sensitive skin. Note that women should not use acne Acne DS Clarifying Gel™ during pregnancy.
In a recent study of 400 women:
In our experience, the longer women take oral spironolactone, the better they do. In fact, many women no longer require topical acne therapy after being on spironolactone for more than a year.
Side effects tend to be mild and include increased urination, low risk of menstrual irregularities, breast tenderness, and headache. Most women do not need to stop spironolactone due to side effects.
It is important to remember that neither topical nor oral spironolactone should be taken during pregnancy. If a woman plans to become pregnant soon, spironolactone is not a good idea. This is because we do not know how spironolactone would affect the development of male genitalia of a fetus (since the medication blocks testosterone receptors).
Any woman using topical or taking oral spironolactone should use an effective form of contraception.
Spironolactone is not used in men due to risks of erectile dysfunction and breast enlargement.
The Acne Center of Michigan was founded to provide acne education and treatment services for the people of Michigan. Combining expertise in dermatology and compassion, we provide a new level of care for our patients.
Monday: 7:30 AM – 4:40 PMTuesday: 7:30 AM – 4:40 PMWednesday: 7:30 AM – 4:50 PMThursday: 7:30 AM – 4:40 PMFriday: 7:30 AM – 1:00 PM